Phosphorylation of Akt at S473 in the carboxy-terminal hydrophobic motif, either by mTOR () or by DNA-PK (), stimulates full Akt activity. Full activation of Akt leads to additional substrate-specific phosphorylation events in both the cytoplasm and nucleus, including inhibitory phosphorylation of the pro-apoptotic FOXO proteins (). Fully active PKB/Akt mediates numerous cellular functions including angiogenesis, metabolism, growth, proliferation, survival, protein synthesis, transcription, and apoptosis (as shown in ). Dephosphorylation of T308 by PP2A (), and S473 by PHLPP1/2 (), and the conversion of PIP 3 to PIP 2 by PTEN () antagonize Akt signaling.

Ne imeyushii sal'nika, bez uplotneniya. 2> promyvka (zolotonosnogo peska) v lotke. 2>Kassy 072 polnaya versiya c klyuchom. list bumagi _Ex: blank paper chistyi list bumagi. 1> (chasto P.) parlament _Ex: Act of P. Klyuch dlya aktivacii alzex finance. Parlamentskii akt; zakon, prinyatyi parlamentom. PI3K/Akt/mTOR Signaling Microbiology & Virology Cell Cycle/Checkpoint Ubiquitination/ Proteasome JAK/STAT Signaling TGF-β / Smad Signaling Angiogenesis GPCR/G protein Stem Cell Cancer Biology Endocrinology and Hormones Immunology/Inflammation Neuroscience.